[{"data":1,"prerenderedAt":312},["ShallowReactive",2],{"project-5672354":3},{"id":4,"name":5,"line":6,"line_source":7,"title":8,"url":9,"domain":10,"maker":11,"posted_at":12,"year":13,"points":14,"comments":15,"rank_in_year":16,"shown_in_year":17,"top":18,"tier":19,"category":20,"subcategory":21,"format":22,"keywords":23,"reception":29,"sentiment":30,"stance_mix":31,"scored_comments":36,"aspects":37,"strip":44,"post_text":46,"what":47,"said":70,"maker_in_thread":174,"shape":176,"grid":180,"attempts":274,"same_week":275,"maker_shows":45,"maker_hidden":304,"reader_version":305,"card":306},"5672354","Nemaload","My friend's project to simulate an entire C. Elegans","title","Show HN: My friend's project to simulate an entire C. Elegans","http:\u002F\u002Fnemaload.davidad.org\u002F","nemaload.davidad.org","SlyShy",1367984415,2013,147,42,135,1739,8,"notable","learning_science","computational neuroscience","other",[24,25,26,27,28],"c elegans","neuron simulation","connectome","calcium imaging","whole brain simulation","curious",0.324,{"positive":32,"neutral":33,"mixed":34,"critical":35},9,16,0,2,27,{"idea":38,"design":40,"pricing":42,"docs":43},{"positive":39,"critical":35},5,{"positive":41,"critical":34},3,{"positive":34,"critical":34},{"positive":34,"critical":34},[34,34,39,34,34,41,39,41,34,34,34,34,34,39,34,34,39,41,45,41,41,41,34,41,34,45,34,41,39,41,41,39,39,41,39,39,41,41,34,41],1,null,{"problem":48,"audience":46,"pricing":46,"motivation":59,"time_to_build":46,"stack":66,"openness":67,"stage":68,"team_size":69},{"value":49,"source":50,"evidence":51},"Building a data-driven simulation of a whole nematode nervous system from in vivo neuron measurements","commenter",[52,56],{"id":53,"by":54,"text":55},"5672572","davidad_","That's about right. My end product is also a computer simulation, as far as that goes, but I'm taking an obsessively data-driven approach, motivated by the advent of new…",{"id":57,"by":54,"text":58},"5672566","Yeah, I haven't updated the site in a while. (This really wasn't the best time for a Hacker News blitz. I was just telling my friend that Nemaload hadn't been on HN yet, as far…",{"value":60,"source":50,"evidence":61},"Pursuing a whole-organism simulation by combining new single-neuron measurement techniques",[62,63],{"id":53,"by":54,"text":55},{"id":64,"by":54,"text":65},"5673141","I like to describe my techniques as \"not novel, just new.\" I'm absolutely building on the work of many others in academia. I've spent time with Engert at Harvard, Rex Kerr at…",[],"unknown","beta","team",{"praise":71,"objections":102,"requests":124,"questions":140,"alternatives":156},[72,87],{"value":73,"source":50,"evidence":74},"Ambitious, interesting project with a clever data-driven approach",[75,79,83],{"id":76,"by":77,"text":78},"5672612","hcarvalhoalves","BTW, what you're attempting blew my mind away. That's a nice hack involving many different disciplines, it will be amazing if you can pull this off.",{"id":80,"by":81,"text":82},"5672480","vitno","Oooh Exciting stuff! I've been following openworm off and on for a while now. The projects should be extremely complementary. I hope they communicate. (This projects is going to…",{"id":84,"by":85,"text":86},"5673904","codeulike","So its not just 'simulate', its more like 'virtualise'. They want to examine neurons in a real worm in real time and then model that. You know all those sci-fi books where people…",{"value":88,"source":50,"evidence":89},"Internship application page with hands-on challenges is well designed",[90,94,98],{"id":91,"by":92,"text":93},"5672990","adventureloop","I love the internship application page http:\u002F\u002Fnemaload.davidad.org\u002Fjobs. The author does expect any candidate to be perfect before meeting, but sets out a small set of criteria…",{"id":95,"by":96,"text":97},"5672887","feniv","I like the \"optional\" hands-on challenges he listed for applicants in the jobs page. It may end up filtering out some talented candidates (not wanting to put in this much effort…",{"id":99,"by":100,"text":101},"5673354","ProblemFactory","The challenges are great because it's not just another meaningless programming test. Instead it's \"week 1\" of the internship, where you learn the background necessary to start…",[103,110,117],{"value":104,"source":50,"evidence":105},"Core techniques are not novel; academics already do most of the pieces",[106],{"id":107,"by":108,"text":109},"5672932","apl","While interesting (especially from a funding perspective!), most of these approaches aren't quite as ground-breaking as one might think. Neuroscientists in academia are doing…",{"value":111,"source":50,"evidence":112},"Uploading to human minds is philosophically doubtful",[113],{"id":114,"by":115,"text":116},"5674242","vidarh","> Isn't that awesome? But ... \"the philosophical assumptions fail, and human immortality through uploading is fundamentally impossible\". To boil it down: They assume roughly that…",{"value":118,"source":50,"evidence":119},"Overly hyped expectations about the maker's potential",[120],{"id":121,"by":122,"text":123},"5673980","lmm","That's an awfully high \"minimum\". I knew several \"geniuses\" at that age (might even qualify myself, though admittedly I was only three years ahead of par at that age); most of…",[125,132],{"value":126,"source":50,"evidence":127},"Try intermediate species such as Drosophila before zebrafish",[128],{"id":129,"by":130,"text":131},"5672915","mbreese","The rest are a bit out of order too... you'd probably want to try Drosophilia before Zebrafish. But yeah, the leap to mouse is pretty huge. You could potentially try to do…",{"value":133,"source":50,"evidence":134},"Better sequencing of the species roadmap, e.g. include lizard or frog",[135,139],{"id":136,"by":137,"text":138},"5672801","ars","The jump from honeybee to mouse is enormous - much larger than any of the other jumps except chimpanzee to human. Maybe try lizard in between them.",{"id":129,"by":130,"text":131},[141,152],{"value":142,"source":50,"evidence":143},"How the uploading claim and philosophy hold up",[144,148],{"id":145,"by":146,"text":147},"5672647","songgao","The about page [1] is very interesting. \"3. Providing a foundation for uploading research .... If it can be done for a worm, the next steps are to attempt a zebrafish, then a…",{"id":149,"by":150,"text":151},"5672888","irollboozers","I'm curious, is the goal to prove one or few models wrong? I think while it is extremely sexy, his explanation kind of answers the question for him in a cheesy way - \"depends on…",{"value":153,"source":50,"evidence":154},"Whether the project will coordinate with OpenWorm",[155],{"id":80,"by":81,"text":82},[157,167],{"value":158,"source":50,"evidence":159},"OpenWorm",[160,164],{"id":161,"by":162,"text":163},"5672457","soccerniru","Interesting .. although a similar project already exists (http:\u002F\u002Fwww.openworm.org\u002F), and is, from a cursory glance, much more developed.",{"id":165,"by":77,"text":166},"5672466","Doesn't seem to be same thing. OpenWorm is computer simulation, while the OP plans to build a model based on observing an actual living individual [1]. [1]…",{"value":168,"source":50,"evidence":169},"Microryza crowdfunding for science",[170],{"id":171,"by":172,"text":173},"5672586","netvarun","Sounds really interesting. You could try to secure additional funding for this project via Microryza (http:\u002F\u002Fwww.microryza.com\u002F), which is a kickstarter for scientific research.",{"comments":34,"answered":34,"key":175},[],{"commenters":177,"max_depth":39,"maker_replies":34,"first_comment_mins":178,"lifespan_hours":179},26,34,19,[181,183,186,190,192,194,196,198,200,202,204,208,210,212,216,219,221,223,227,229,230,231,233,236,239,240,242,243,244,245,247,250,254,256,258,260,261,262,265,266,269,272],[107,34,34,182,108,34],"commenter\u002Fneutral\u002Fidea",[184,34,34,182,185,34],"5673097","DaniFong",[187,34,39,188,189,34],"5673123","maker\u002Fpositive\u002Fnone","Hitchhiker",[121,34,34,191,122,34],"commenter\u002Fneutral\u002Fnone",[193,34,34,191,189,34],"5674606",[64,34,41,195,54,34],"maker\u002Fneutral\u002Fidea",[91,45,39,197,92,34],"project\u002Fpositive\u002Fdesign",[171,35,41,199,172,34],"project\u002Fneutral\u002Fpricing",[201,35,34,191,189,34],"5672681",[203,35,34,182,150,34],"5672823",[205,35,34,206,207,34],"5672951","other\u002Fneutral\u002Fnone","kanzure",[209,35,34,191,150,34],"5672957",[211,35,34,191,207,34],"5674683",[213,41,39,214,215,34],"5672562","project\u002Fpositive\u002Fidea","dylangs1030",[217,41,34,206,218,34],"5673661","sweettea",[220,41,34,191,185,34],"5677364",[145,222,39,214,146,34],4,[224,222,41,225,226,34],"5672669","project\u002Fneutral\u002Fidea","darshan",[149,222,45,228,150,34],"project\u002Fcritical\u002Fidea",[136,222,41,225,137,34],[129,222,41,225,130,34],[232,222,41,225,54,34],"5672970",[234,222,41,225,235,34],"5672885","noonespecial",[237,222,34,206,238,34],"5672989","cpeterso",[114,222,41,225,115,34],[241,222,34,182,85,34],"5674430",[161,39,45,228,162,34],[165,39,34,182,77,34],[53,39,41,195,54,34],[76,39,39,246,77,34],"maker\u002Fpositive\u002Fidea",[248,39,41,249,207,34],"5672628","maker\u002Fneutral\u002Fnone",[251,39,41,252,253,34],"5673279","project\u002Fneutral\u002Fdocs","bntlyb",[84,255,39,214,85,34],6,[80,257,39,214,81,34],7,[259,257,41,249,54,34],"5672538",[95,18,39,197,96,34],[99,18,39,197,100,34],[263,32,41,264,189,34],"5672491","project\u002Fneutral\u002Fnone",[57,32,41,249,54,34],[267,32,34,206,268,34],"5672604","rmrfrmrf",[270,32,41,271,54,34],"5672789","maker\u002Fneutral\u002Fdocs",[273,32,41,271,54,34],"5673205",[],[276,281,286,291,296,300],{"id":277,"name":278,"points":279,"category":280},"5672515","Flattest Route",237,"dev_tools",{"id":282,"name":283,"points":284,"category":285},"5643801","Weekend project",196,"languages",{"id":287,"name":288,"points":289,"category":290},"5675229","Uncover",178,"web_saas",{"id":292,"name":293,"points":294,"category":295},"5663041","Zapier API Status Board",143,"infrastructure",{"id":297,"name":298,"points":299,"category":285},"5645787","Quasar \u002F Pulsar",116,{"id":301,"name":302,"points":303,"category":290},"5661974","Freelancer Sticker",75,false,"v2",{"id":307,"name":5,"line":6,"ai":304,"cat":20,"year":13,"points":14,"comments":15,"rec":29,"s":308,"top":18,"kw":309,"maker":11,"domain":10,"tier":19,"attempts":34,"strip":310,"url":9,"mix":311,"praise":73,"objection":104,"sub":21},5672354,0.32,[24,25,26,27,28],"0050035300000500531333030103533553553303",[32,33,34,35],1793990894006]