AlphaFold3
AI
protein structure prediction
SHOW HN2024
314points
37comments
#188of 3,515 in 2024
Top 6%of 2024 by points
How HN took it
CuriousMostly questions and neutral comments
3 positive, 9 neutral or asking, 0 mixed, 1 critical, out of 13 comments about the project. Thread score +0.07.
The thread, comment by comment
Each row is a top-level comment and its replies, in HN's order. Select a cell to open that comment on HN.
positive neutral or mixed critical about another commenter or something else the maker
What HN said
What people liked
Welcomed as a truly open version usable commercially
From 1 comment
Thanks for releasing this, I've been looking forward to a truly open version I can use in a commercial setting. What a way to launch the company!
boldlybold on HN
Objections
Name may infringe DeepMind's trademark; implementation is not truly AlphaFold3
From 1 comment
You probably want to change the name of this implementation as it's not truly AlphaFold3. I wouldn't be surprised if you got a C&D from DM for using the name.
dekhn on HN
Weights and benchmarks not yet released; model only partially trained
From 2 comments
The predictions can be verified by comparing the predicted structure to the experimentally solved structure, either crystal or cryoEM. The model is still training and improving,…
EdHarris on HN- The maker's post
Requests
Rename the project
From 1 comment
You probably want to change the name of this implementation as it's not truly AlphaFold3. I wouldn't be surprised if you got a C&D from DM for using the name.
dekhn on HN
Questions
What is the business plan and what is being sold
From 1 comment
This seems really neat! DeepMind and AlphaFold are clearly moving in a closed-source direction, since they created Isomorphic Labs as a division of Alphabet essentially focused…
lacker on HN
How are predictions verified against experiment
From 1 comment
Hi, how are predictions verified? Does one still do experimental techniques (X-ray crystallography, cryogenic-em etc.) one you have the prediction? Or are predictions so close to…
dwayne_dibley on HN
Alternatives named
OpenFold
From 1 comment
ColabFold
From 1 comment
Are you familiar with ColabFold? https://github.com/sokrypton/ColabFold
inciampati on HN